Varenicline, nicotine-containing e-cigarettes help you quit smoking

WEDNESDAY, June 19, 2024 (HealthDay News) — Varenicline and nicotine-containing electronic cigarettes (ECs) are both effective in helping individuals quit smoking conventional cigarettes, according to a study published online June 17 in JAMA Internal Medicine.

Anna Tuisku, Ph.D., of Lapland Central Hospital in Finland, and colleagues randomly assigned 458 participants (aged 25 to 75) who smoked daily and had volunteered to quit smoking to receive 18 mg/ml nicotine-containing ECs together with placebo tablets, standard-dose Fernicline together with nicotine-free ECs, or placebo tablets together with nicotine-free ECs.

The researchers found that self-reported seven-day abstinence from conventional smoking, as confirmed by exhaled carbon monoxide levels at week 26, occurred in 40.4 percent in the EC group, 43.8 percent in the varenicline group, and 19.7 percent in the placebo group. There were significant differences between placebo and ECs (risk difference (RD), 20.7 percent) and varenicline (RD, 24.1 percent). The difference was not significant between ECs and Varenicline (RD, 3.4 percent).

“Weighing the benefits of nicotine-containing ECs for smoking cessation against the known harms and uncertainty surrounding their long-term consumption, it appears that they may play a role in reducing tobacco-related health harm in adults who are substantially dependent on nicotine and have been smoking for many years and, despite several attempts, have not been able to quit smoking conventional cigarettes,” the authors write.

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